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Animal Study Shows Liver Health Benefits of Mixed Vitamin E

Non-alcoholic steatohepatitis (NASH) is the most advanced form of non-alcoholic fatty liver disease. A recent animal study suggests that taking d-mixed tocotrienols together with alpha-tocopherol may improve liver health, while taking just one type of vitamin E showed no similar results.

Vitamin E has eight different forms: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Tocopherol is the most common form in both the American diet and European diets. Tocotrienols are less prominent in the Western diet.

The researchers gave rats either d-mixed tocotrienols, alpha-tocopherols, or a mixture of both. They found that only the mixture resulted in improved markers of liver health.

Researchers from the Kanagawa Institute of Technology and Eisai Food & Chemical Co. in Japan conducted the study. It was published in the March 2013 issue of the Journal of Clinical Biochemistry and Nutrition.

This is not the first study to examine the effects of vitamin E on non-alcoholic fatty liver disease. Researchers from the Universiti Sains Malaysi conducted a study in 2010 where
participants with non-alcoholic fatty liver disease were given 200 mg of a tocotrienol complex twice daily for one year. At the end of the year, 67% of the participants showed significant improvements and 50% showed no signs of the disease anymore.

Previous studies have also shown that vitamin E intake is associated with lower cholesterol, healthier skin, maintaining a proper hormonal balance, and preventing amyotrophic lateral sclerosis (ALS).

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