Skip to content
Old Woman Hand on Face Elderly

Chronic Inflammation In Middle Age May Increase Risk of Cognitive Decline Later In Life

Chronic inflammation is a low-grade inflammation that lingers for months or even years in the body. Symptoms include joint pain or stiffness, digestive problems, and fatigue. A new study has found that chronic inflammation in middle age may lead to cognitive decline later in life.


12,336 people who were part of the Atherosclerosis Risk in Communities Study participated in this study. Blood samples were taken at the start of the study to measure four biomarkers of inflammation: fibrinogen, white blood cell count, von Willebrand factor, and factor VIII. The researchers created a composite inflammation score for the four biomarkers. C-reactive levels were measured three years into the study. Participants’ thinking and memory skills were tested at baseline, six to nine years later, and at the end of the study.


Participants with the highest levels of inflammation biomarkers were found to have an 8% higher decline in thinking and memory skills compared to those with the lowest levels of inflammation biomarkers. Participants with the highest C-reactive protein levels had a 12% higher decline in thinking and memory compared to those with the lowest levels. These results held even after researchers adjusted for other factors such as education, heart disease, and high blood pressure.


The study was conducted by researchers from Johns Hopkins University. It was published online ahead of print on February 13, 2019 in the journalNeurology.

Previous article Weekly Sexual Activity May Decrease Risk of Early Menopause

Related Posts

Avocados May Help Improve Focus in Obese Adults
Avocados May Help Improve Focus in Obese Adults
Body fat and an unhealthy diet may impair brain function and lead to cognitive problems. A recent study suggests that...
Read More
Taking More Steps Daily May Help Improve Blood Pressure
Taking More Steps Daily May Help Improve Blood Pressure
Making lifestyle changes such as losing weight, increasing activity, stopping smoking, and reducing stress is suggest...
Read More
Omega-3 Supplementation May Help Reduce Urine Protein in Type 2 Diabetics
Omega-3 Supplementation May Help Reduce Urine Protein in Type 2 Diabetics
Proteinuria is the presence of abnormal quantities of protein in the urine and is a marker of kidney damage in diabet...
Read More