Microvascular Endothelial Dysfunction Associated with Increased Risk of Cancer
Microvascular dysfunction is a type of non-obstructive coronary artery disease that causes the small blood vessels feeding the heart muscle to not work as they should and is an early sign of cardiovascular disease. A new study has found that microvascular endothelial dysfunction may be associated with a two-fold increased risk of solid-tumor cancer.
The researchers looked at the data for 488 people who were assessed for microvascular endothelial dysfunction between 2006 and 2014. Of those, 221 were diagnosed with microvascular endothelial dysfunction, meaning they had a tonometry index at or below 2. All the participants were followed for an average of 6 years.
During the follow-up period, 9.7% of the participants previously diagnosed with microvascular endothelial dysfunction were diagnosed with solid-tumor cancer. In comparison, only 3.7% of the participants diagnosed as not having microvascular endothelial dysfunction were diagnosed with solid-tumor cancer. These findings held even after adjusting for age, sex, diabetes, hypertension, and smoking status.
The study was conducted by researchers from the Mayo Clinic. It was published online ahed of print on October 31, 2019 in the European Journal of Preventive Cardiology.