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Supplement Combination Shows Promise for Knee Osteoarthritis Relief

Knee osteoarthritis is a degenerative disease of the knee joint, commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. However, long term use of NSAID’s can have serious side effects such as ulcers, kidney failure and liver failure.

A recent study from researchers at FutureCeuticals, Inc. suggests that a supplement consisting of boron, calcium and fructose may reduce inflammation and pain in knee osteoarthritis sufferers. Their findings were published online ahead of print in the 2012 issue of the American Journal of Biomedical Sciences.

Twenty volunteers between the ages of 44 and 65 participated in the two-week double-blind, placebo-controlled pilot study. All of the volunteers had knee osteoarthritis, as confirmed by CT scan.

Half of the group consumed a fructose placebo, while the other half consumed a 108 mg supplement twice daily. The researchers drew blood at the onset of the study, at the 7 day mark and after 14 days to measure blood levels of c-reactive protein (CRP) and 1,25-Dihydroxy vitamin D. To measure pain, the volunteers completed the Western Ontario and McMaster Universities and Osteoarthritis Index (WOMAC) and the McGill pain questionnaire.

At the 7 day mark, the participants taking the supplement were already noting reductions in pain and stiffness and improvements in physical function. By the end of the study, the participants saw a 29% improvement in the WOMAC scores and 14% in the McGill scores.

The participants taking the supplement also saw improvements in the two biomarkers of osteoarthritis. CRP was reduced up to 37% compared to baseline levels in seven out of 10 volunteers and blood levels of 1,25(OH) vitamin D showed a 19% increase. The vitamin D increase is notable as previous studies have shown that it may help bone and cartilage health.

Osteoporosis affects 4 times as many women as men, however it can strike either gender. In addition to the nutrients listed here, soy isoflavone genistein, omega-3 essential fatty-acids, and vitamin D3, vitamins K1 and K2 and ashwaganda extract have been shown to improve bone health. All of these nutrients are difficult to obtain through diet alone but a daily high quality supplement can boost your blood levels.

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