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Vitamin B5 Derivative Shown to Lower Cholesterol

High cholesterol has been shown to contribute to heart disease. The most common treatment – statins – is associated with negative side effects, including lower CoQ10 levels. A recent study found that taking daily supplements of pantethine (a vitamin B5 derivative) may lower LDL cholesterol by 11% and total cholesterol by 6%.

Participants in the study included 32 North Americans who were eligible for statin therapy. They took either 600 mg/day from weeks 1 to 8 of the trial and then 900 mg/day from weeks 9 to 16 or a placebo.

At the conclusion of the study the supplement group showed a 6% decrease in total cholesterol as well as an 11% decrease in LDL cholesterol. In comparison, the placebo group had a 3% increase in LDL cholesterol.

Homocysteine levels stayed level in both groups while CoQ10 levels increased by the four week mark and stayed high for the remainder of the trial for both groups. Statin therapy has been shown to reduce CoQ10 to detrimental levels.

Researchers from KGK Synergize, The Princeton Longevity Center, Daiichi Fine Chemical Co and Kyowa Hakko USA conducted the study. It was published on February 27, 2014 in Vascular Health and Risk Management.

Vitamin B5 has been linked to stress reduction, clearing acne, improving allergies, and hormone regulation. This vitamin can be found in many foods, including meats, eggs, milk, yeast, legumes, mushrooms, and whole wheat. If you think you’re not getting enough vitamin B though diet alone, try a high quality daily supplement.

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